Experience of 100 solid organ transplants over a five-yr period from the first successful pediatric multi-organ...

Area of Science:

• Pediatric Surgery
• Transplantation Medicine
• Nephrology

Background:

• Solid organ transplantation is a critical intervention for pediatric end-stage organ disease.
• Understanding clinical profiles and outcomes is essential for improving patient care.
• Established centers provide benchmarks for evaluating transplant program performance.

Purpose of the Study:

• To analyze the clinical profile and outcomes of pediatric liver and renal transplant recipients.
• To evaluate the survival rates and common complications following these procedures.
• To compare the center's transplant outcomes with international standards.

Main Methods:

• Retrospective analysis of case records for pediatric patients undergoing liver or renal transplant.
• Data collection included transplant type, indications, post-operative complications, and survival rates.
• Follow-up duration ranged from two years three months to three years.

Main Results:

• 100 solid organ transplants performed: 50 liver, 44 renal, 1 sequential liver and renal, 2 CLKT.
• Biliary atresia (38%) was the most common indication for liver transplant (LT); survival was 88% at 2 years 3 months.
• Chronic glomerulonephritis (54.5%) was the most common indication for renal transplant (RT); survival was 91% at 3 years.

Conclusions:

• Pediatric liver and renal transplant survival rates at this center are comparable to established Western centers.
• Common post-operative complications include infections, vascular issues, and graft dysfunction.
• Living related grafts were utilized for all procedures, with CLKT performed for hyperoxaluria.