Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

4.2K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
Neurulation01:30

Neurulation

40.1K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.1K
Fetal Circulation01:14

Fetal Circulation

5.0K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
5.0K
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

39.3K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
39.3K
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

4.5K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A digital microfluidic platform for cell-based non-invasive testing.

iScience·2026
Same author

A next-generation episignature for Kabuki syndrome enables fine mapping of the impact of KMT2D variants to inform precision medicine.

American journal of human genetics·2026
Same author

Pathogenic variants in BORCS5 cause a spectrum of neurodevelopmental and neurodegenerative disorders with lysosomal dysfunction.

The Journal of clinical investigation·2026
Same author

Diagnostic yield and imaging: aetiology correlations in prenatal intracranial haemorrhage-a retrospective cohort study.

Archives of disease in childhood. Fetal and neonatal edition·2026
Same author

The fetal taenia-tela choroidea complex: a radiologic-pathologic correlation from normal anatomy to Dandy-Walker malformation.

Pediatric radiology·2026
Same author

Examining aspects of job satisfaction associated with burnout and factors related to turnover intention in genetic counselors.

Journal of genetic counseling·2026
Same journal

Correction to: Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.

Acta neuropathologica communications·2026
Same journal

A rare missense variant impacting NEK1 kinase function is associated with ALS.

Acta neuropathologica communications·2026
Same journal

VGLL-fused intraparenchymal schwannoma with EWSR1::VGLL1 fusion: integrated clinicopathological and molecular characterization.

Acta neuropathologica communications·2026
Same journal

Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury.

Acta neuropathologica communications·2026
Same journal

Dynamic integration of skeletal muscle signals via extracellular vesicles in motor neuron diseases.

Acta neuropathologica communications·2026
Same journal

Low-input CSF cfDNA shallow whole-genome sequencing for CNV-based diagnosis and monitoring of leptomeningeal metastasis in lung cancer.

Acta neuropathologica communications·2026
See all related articles

Related Experiment Video

Updated: Apr 26, 2026

Murine Fetal Echocardiography
08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

17.2K

Fetal syringomyelia.

Anne Guo, David Chitayat, Susan Blaser

    Acta Neuropathologica Communications
    |August 6, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Fetal syringomyelia, often seen in Chiari II malformations and other spinal dysraphisms, can develop early in gestation. It results from primary malformations and secondary in-utero injury, differing from post-natal cases.

    More Related Videos

    Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
    05:44

    Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

    Published on: May 17, 2024

    1.2K
    A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
    08:19

    A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

    Published on: December 16, 2022

    2.3K

    Related Experiment Videos

    Last Updated: Apr 26, 2026

    Murine Fetal Echocardiography
    08:04

    Murine Fetal Echocardiography

    Published on: February 15, 2013

    17.2K
    Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
    05:44

    Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

    Published on: May 17, 2024

    1.2K
    A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
    08:19

    A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

    Published on: December 16, 2022

    2.3K

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Pediatric Pathology

    Background:

    • Syringomyelia is a complex spinal cord condition.
    • Fetal spinal dysraphism and hindbrain crowding are associated with neurological abnormalities.
    • Understanding the origins of fetal syringomyelia is crucial for diagnosis and management.

    Purpose of the Study:

    • To determine the prevalence of syringomyelia in fetuses with dysraphism and hindbrain crowding.
    • To characterize the anatomical features and potential causes of fetal syringomyelia.
    • To differentiate fetal syringomyelia from post-natal forms.

    Main Methods:

    • Retrospective analysis of 113 fetal cases (17.5–34 weeks gestation).
    • Examination of cases with Chiari II malformations, OEIS, Meckel Gruber syndrome, and conjoined twins.
    • Histopathological assessment for secondary injury markers like vernicomyelia and hemorrhage.

    Main Results:

    • Syringomyelia was identified in 13 cases of Chiari II malformations, 5 OEIS cases, 2 Meckel Gruber syndrome cases, and 1 conjoined twin pair.
    • Secondary injuries (vernicomyelia, infarct-like histology, hemorrhage) were observed in 8 cases.
    • Syringes were typically distinct from the central canal, located dorsally/paramedially, and extended proximally or distally from dysraphic sites.

    Conclusions:

    • Fetal syringomyelia in Chiari II malformations and dysraphic states often forms before midgestation.
    • Both primary malformation and secondary in-utero injury contribute to its development.
    • Fetal syringomyelia is anatomically and pathophysiologically distinct from post-natal syringomyelia secondary to hindbrain crowding.