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Related Concept Videos

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Antigen presenting cell-derived IL-6 restricts Th2-cell differentiation.

Alice Mayer1, Delphine Debuisson, Sébastien Denanglaire

  • 1Laboratoire d'Immunobiologie, Institut de Biologie et de Médecine Moléculaire, Université Libre de Bruxelles, Gosselies, Belgium.

European Journal of Immunology
|August 6, 2014
PubMed
Summary

Interleukin-6 (IL-6) secreted by dendritic cells (DCs) suppresses Th2 immune responses. DCs control Th2 immunity magnitude through IL-6, impacting T helper cell differentiation and allergic inflammation.

Keywords:
Airway allergyDCsIL-6Th2-cell differentiationiNKT cells

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) orchestrate Th1 and Th17 immune responses.
  • The role of DC-derived signals in regulating Th2 immune responses is largely unknown.

Purpose of the Study:

  • To investigate the role of DC-derived signals in the regulation of Th2 immune responses.
  • To identify specific DC-derived signals that influence Th2 cell differentiation.

Main Methods:

  • Administration of antigen-loaded, IL-6-deficient DCs to naïve mice.
  • Coinjection of wild-type and IL-6-deficient bone marrow-derived dendritic cells (BMDCs).
  • In vitro assessment of IL-6's effect on Th2 cell differentiation.

Main Results:

  • IL-6-deficient DCs induced an exacerbated Th2 response.
  • IL-6 negatively influenced Th2-cell development in vivo and in vitro.
  • iNKT cells were required for optimal Th2-cell differentiation.

Conclusions:

  • DC-derived IL-6 is a major mechanism controlling the magnitude of Th2 immunity.
  • IL-6 secretion by DCs suppresses Th2 cell differentiation and allergic inflammation.