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Updated: Apr 26, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute kidney injury in the pediatric cardiac patient
David M Axelrod1, Scott M Sutherland
1Division of Cardiology, Department of Pediatrics, Stanford University Medical Center, Palo Alto, CA, USA. daxelrod@stanford.edu.
Insights
Acute kidney injury (AKI) following pediatric congenital cardiac surgery poses significant challenges. Early detection and standardized definitions are crucial for improving patient outcomes and long-term survival.
Area of Science:
- Pediatric cardiac surgery
- Nephrology
- Intensive care medicine
Background:
- Acute kidney injury (AKI) is a critical complication in pediatric congenital cardiac surgery.
- Postoperative AKI is linked to adverse short-term outcomes and long-term risks including chronic kidney disease and mortality.
Discussion:
- AKI presents diagnostic and therapeutic challenges in the intensive care unit.
- The condition is associated with increased patient morbidity, healthcare costs, and mortality.
- Urgent attention from clinicians and researchers is required.
Key Insights:
- Pediatric congenital cardiac surgery-associated AKI requires immediate clinical and research focus.
- AKI impacts short-term recovery and long-term health trajectories.
- Standardized AKI definitions are essential for future research.
Outlook:
- Future studies must adopt uniform AKI definitions.
- Research should prioritize AKI mitigation and prevention strategies.
- Improving AKI management is vital for pediatric cardiac surgery patients.
Abstract:
In summary, AKI after pediatric congenital cardiac surgery represents an important diagnostic and therapeutic challenge in the modern day intensive care unit. AKI in the immediate postoperative period not only portends a poor short-term outcome, but also may relate to chronic kidney disease and mortality in the long term. Its association with increased morbidity, cost, and mortality demands the attention of clinicians and researchers. Future studies should employ a standard AKI definition and should focus on both the mitigation and prevention of AKI events.
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction
Acute Kidney Injury V: Interprofessional Care
Cardiac Catheterization I: Pre-Procedure Overview
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury II: Pathophysiology

