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A young patient with a family history of hypertension

Aldo J Peixoto1

  • 1Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut aldo.peixoto@yale.edu.

Clinical Journal of the American Society of Nephrology : CJASN
|August 6, 2014
PubMed

Insights

Evaluating hypertension in young adults with a family history requires identifying treatable causes like those in autosomal dominant polycystic kidney disease. Aldosterone may play a role in cyst growth and hypertension.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Hypertension in young adults with a family history necessitates methodical evaluation for treatable causes.
  • Standard evaluation includes renal imaging and hormonal assays (plasma aldosterone, plasma renin activity).

Observation:

  • Autosomal dominant polycystic kidney disease (ADPKD) presents unique hypertension challenges.
  • Endothelial dysfunction is implicated in early hypertension within ADPKD.
  • Treatment strategies for ADPKD-related hypertension are reviewed.

Findings:

  • The potential link between ADPKD and primary aldosteronism is explored.
  • Evidence for a direct connection is limited.
  • Aldosterone excess and hypokalemia may promote ADPKD cyst growth.

Implications:

  • This review highlights the importance of considering endocrine factors in ADPKD management.
  • Further research is needed to clarify the relationship between aldosterone and ADPKD progression.
  • Understanding these links can lead to improved hypertension management in affected individuals.

Keywords:
aldosteronegenetic renal diseasehyperaldosteronismhypertensionpolycystic kidney disease

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