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Published on: October 23, 2020
Cognitive function and the risk for diabetes among young men
Gilad Twig1, Israel Gluzman2, Amir Tirosh3
1Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel Dr. Pinchas Bornstein Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel Israel Defense Forces Medical Corps, Israel gilad.twig@gmail.com.
Lower cognitive function in adolescence is linked to a higher risk of developing diabetes later in life. This finding suggests cognitive ability may predict future diabetes incidence.
Area of Science:
- Neuroscience
- Endocrinology
- Public Health
Background:
- Diabetes mellitus is a known risk factor for accelerated cognitive decline and dementia.
- The bidirectional relationship between cognitive function and diabetes development requires further investigation.
Purpose of the Study:
- To investigate the association between cognitive function in late adolescence and the subsequent risk of developing diabetes.
- To determine if lower cognitive function predicts future diabetes incidence independently of other risk factors.
Main Methods:
- A historical-prospective cohort study was conducted using data from Israeli military conscripts.
- Cognitive function was assessed using the General Intelligence Score (GIS) at age 17.
- Follow-up data on diabetes incidence were collected from military health records.
Main Results:
- Among 35,500 men, 770 developed diabetes over a median follow-up of 5.5 years.
- Men in the lowest GIS category had a 2.6-fold increased risk of diabetes compared to the highest category.
- Even after adjusting for BMI, glucose levels, and lifestyle factors, the lowest GIS category showed a twofold higher risk of incident diabetes (HR 2.1).
Conclusions:
- Lower cognitive function in late adolescence is an independent predictor of elevated future diabetes risk.
- This association suggests a potential link between early-life cognitive abilities and metabolic health later in life.
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