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Updated: Apr 26, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis
Feng Sun1, Qiaoling Ruan2, Jiali Wang2
1Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China zhangwenhong@fudan.edu.cn.
Abstract:
We conducted a retrospective cohort study of patients with MRC grade II/III tuberculous meningitis (TBM) who accepted a background antitubercular regimen (BR) with or without linezolid (LZD). At the 4th week, the LZD-BR group achieved a faster and higher percentage of Glasgow coma scale recovery and temperature recovery, a higher cerebrospinal fluid (CSF)/blood glucose ratio, and lower CSF white blood cell counts than did the BR group. Short-term linezolid supplementation may be a more effective treatment for life-threatening TBM.
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