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Delayed atrophy in posterior cingulate cortex and apathy after stroke.

Kiwamu Matsuoka1, Fumihiko Yasuno, Akihiko Taguchi

  • 1Department of Psychiatry, Nara Medical University, Kashihara, Japan.

International Journal of Geriatric Psychiatry
|August 6, 2014
PubMed
Summary

Stroke can cause delayed brain atrophy, particularly in the posterior cingulate cortex (PCC). This structural change over six months is linked to increased apathy in stroke survivors.

Keywords:
apathymagnetic resonance imagingposterior cingulate cortexstrokevoxel-based morphometric analysis

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Chronic structural changes after stroke are not fully understood.
  • Previous research has limited data on long-term brain alterations post-stroke.

Purpose of the Study:

  • Investigate regional cortical volume changes following stroke onset.
  • Examine the relationship between cortical volume changes and neuropsychiatric symptoms.

Main Methods:

  • Utilized T1-MRI scans from 20 stroke patients and 14 controls at subacute and 6-month follow-up stages.
  • Employed whole-brain voxel-based morphometry (VBM) to identify cortical gray matter volume changes.
  • Assessed correlations between cortical volume alterations and neuropsychiatric symptom changes over six months.

Main Results:

  • Identified significant volume reductions in the anterior posterior cingulate cortex (PCC) within six months post-stroke.
  • Found a significant correlation between the extent of PCC volume change and changes in apathy scale scores.

Conclusions:

  • Stroke can lead to delayed atrophic changes in the PCC six months after the event.
  • Greater volume reductions in the PCC were associated with increased apathy in stroke patients.
  • Delayed PCC atrophy may result from secondary degeneration, impacting goal-directed behavior and contributing to apathy.