Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

791
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
791
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

228
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
228
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

2.0K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
2.0K
Roles of Electrolytes: Chloride and Bicarbonate01:29

Roles of Electrolytes: Chloride and Bicarbonate

1.4K
Chloride ions contribute to the osmotic pressure gradient distinguishing the intracellular fluid (ICF) from the extracellular fluid (ECF). They counterbalance positively charged ions in the ECF and ensure its electrochemical stability. The renal system's process of chloride absorption and release generally mirrors that of sodium ions.
Conditions such as hypochloremia can arise from insufficient chloride reabsorption by the kidneys, often compounded by extended bouts of diarrhea, vomiting,...
1.4K
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

291
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
291
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

670
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
670

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct Clinical Evidence Recommending the Use of Proteinase K or Dithiothreitol to Pretreat Sputum for Detection of SARS-CoV-2.

Frontiers in medicine·2020
Same author

Simulating rainfall runoff and assessing low impact development (LID) facilities in sponge airport.

Water science and technology : a journal of the International Association on Water Pollution Research·2020
Same author

Resolution Improvement of Light Field Imaging via a Nematic Liquid Crystal Microlens with Added Multi-Walled Carbon Nanotubes.

Sensors (Basel, Switzerland)·2020
Same author

The Recommendations for the Management of Chinese Children With Epilepsy During the COVID-19 Outbreak.

Frontiers in pediatrics·2020
Same author

Effects of caprolactam content on curdlan-based food packaging film and detection by infrared spectroscopy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2020
Same author

MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer.

BioMed research international·2020

Related Experiment Video

Updated: Apr 26, 2026

The Tail Suspension Test
10:17

The Tail Suspension Test

Published on: January 28, 2012

81.8K

Case report on lithium intoxication with normal lithium levels.

Jing Peng1

  • 1Xiaogan Rehabilitation Hospital, Xiaogan, Hubei Province, China.

Shanghai Archives of Psychiatry
|August 6, 2014
PubMed
Summary

Lithium bicarbonate effectively treated mania, but intoxication can occur even with low blood levels. Close clinical monitoring for lithium intoxication symptoms is crucial for patient safety.

Keywords:
adverse reactionscase reportlithium intoxicationlithium serum levelsmanic episode

More Related Videos

In Situ Lithiated Reference Electrode: Four Electrode Design for In-operando Impedance Spectroscopy
09:36

In Situ Lithiated Reference Electrode: Four Electrode Design for In-operando Impedance Spectroscopy

Published on: September 12, 2018

8.2K
1,3,5-Triphenylbenzene and Corannulene as Electron Receptors for Lithium Solvated Electron Solutions
06:56

1,3,5-Triphenylbenzene and Corannulene as Electron Receptors for Lithium Solvated Electron Solutions

Published on: October 10, 2016

6.9K

Related Experiment Videos

Last Updated: Apr 26, 2026

The Tail Suspension Test
10:17

The Tail Suspension Test

Published on: January 28, 2012

81.8K
In Situ Lithiated Reference Electrode: Four Electrode Design for In-operando Impedance Spectroscopy
09:36

In Situ Lithiated Reference Electrode: Four Electrode Design for In-operando Impedance Spectroscopy

Published on: September 12, 2018

8.2K
1,3,5-Triphenylbenzene and Corannulene as Electron Receptors for Lithium Solvated Electron Solutions
06:56

1,3,5-Triphenylbenzene and Corannulene as Electron Receptors for Lithium Solvated Electron Solutions

Published on: October 10, 2016

6.9K

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Lithium is a common mood stabilizer for bipolar disorder.
  • Therapeutic drug monitoring of lithium levels is standard practice.

Observation:

  • An 18-year-old female experienced mania, treated successfully with lithium bicarbonate.
  • Post-discharge, she presented with symptoms of lithium intoxication despite a low blood lithium level (0.57 mmol/L).

Findings:

  • The patient exhibited anuria, trembling extremities, blurred speech, muscle rigidity, and hyperactive reflexes, indicative of lithium toxicity.
  • Intravenous mannitol rapidly resolved the acute intoxication symptoms.

Implications:

  • Clinical assessment of lithium intoxication symptoms is vital, irrespective of blood lithium levels.
  • Enhanced patient and physician education on lithium toxicity recognition and management is necessary.