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Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Lanthanide-doped upconversion nano-bioprobes: electronic structures, optical properties, and biodetection
Wei Zheng1, Ping Huang, Datao Tu
1Key Laboratory of Optoelectronic Materials Chemistry and Physics, and Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China. xchen@fjirsm.ac.cn.
Chemical Society Reviews
|August 6, 2014
Summary
Lanthanide-doped upconversion nanoparticles (UCNPs) offer superior biological imaging due to their unique optical properties. This review details their photophysics and applications in detecting tumor markers.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Optics
Background:
- Lanthanide-doped upconversion nanoparticles (UCNPs) possess advantageous optical properties like large anti-Stokes shifts and low autofluorescence.
- These features make UCNPs suitable alternatives to traditional bioprobes (organic dyes, quantum dots) for biological applications.
- Understanding UCNP photophysics is crucial for developing novel optical properties and applications.
Purpose of the Study:
- To review recent advancements in lanthanide-doped UCNPs for luminescent nano-bioprobes.
- To explore the fundamental photophysics of UCNPs, including electronic structures and excited-state dynamics.
- To highlight UCNP applications in in vitro biodetection of tumor markers.
Main Methods:
- Utilized customized lanthanide photophysics measurement platforms designed for upconversion luminescence.
- Investigated electronic structures (energy levels, local site symmetry) of emitters.
- Analyzed excited-state dynamics and optical property design strategies.
Main Results:
- Detailed review of recent progress in lanthanide-doped UCNPs.
- Comprehensive analysis of UCNP photophysics from fundamental principles to bioapplications.
- Demonstrated promising applications in in vitro tumor marker detection.
Conclusions:
- Lanthanide-doped UCNPs show significant potential as luminescent nano-bioprobes.
- Further research into UCNP photophysics will unlock new optical properties and applications.
- UCNPs are poised for advancement in biodetection and other biomedical fields.
