Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 26, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

19.5K

Microfluidic organs-on-chips.

Sangeeta N Bhatia1, Donald E Ingber2

  • 11] Department of Electrical Engineering &Computer Science, Koch Institute and Institute for Medical Engineering and Science, Massachusetts Institute of Technology and Broad Institute, Cambridge, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Nature Biotechnology
|August 6, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In vitro</i> recapitulation of intramuscular mRNA vaccination with naive and recall antigens using a human lymphoid follicle chip platform.

iScience·2026
Same author

Human organ-on-a-chip technology as a catalyst for drug discovery.

Advanced drug delivery reviews·2026
Same author

Deep learning-enabled discovery of antibiotics effective against <i>Neisseria gonorrhoeae</i>.

Science translational medicine·2026
Same author

Correction: MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome.

Acta neuropathologica communications·2026
Same author

Probiotic intervention mitigates radiation-induced intestinal injury by alleviating oxidative stress in a human gut-on-a-chip.

Scientific reports·2026
Same author

Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects.

Nature biomedical engineering·2026

Organ-on-a-chip technology uses microfluidic devices to mimic human organ physiology for advanced research. These systems offer superior in vitro models for studying tissue development, disease, and drug discovery.

Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Microfluidics

Background:

  • Conventional cell culture methods (2D, 3D) have limitations in replicating complex organ physiology.
  • There is a need for advanced in vitro models that accurately simulate human tissue and organ functions.
  • Organ-on-a-chip technology offers a novel solution to bridge the gap between traditional cell cultures and in vivo systems.

Purpose of the Study:

  • To introduce and describe the capabilities of organ-on-a-chip technology.
  • To highlight the potential of these devices in advancing biological research and drug development.
  • To emphasize the advantages over existing cell culture systems.

Main Methods:

  • Utilizes microchip manufacturing techniques to create microfluidic devices.

More Related Videos

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

32.0K
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.1K

Related Experiment Videos

Last Updated: Apr 26, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

19.5K
The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

32.0K
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.1K
  • Incorporates continuously perfused chambers with living cells to simulate organ-level physiology.
  • Replicates multicellular architectures, tissue interfaces, microenvironments, and vascular perfusion.

    • Main Results:

    • Achieves unprecedented levels of tissue and organ functionality in vitro.
    • Enables high-resolution, real-time imaging of cellular activities.
    • Facilitates in vitro analysis of biochemical, genetic, and metabolic processes within a functional tissue context.

    Conclusions:

    • Organ-on-a-chip technology holds significant potential for advancing the study of tissue development, organ physiology, and disease etiology.
    • These devices are exceptionally valuable for drug discovery and development, including mechanism of action studies, candidate prioritization, toxicity testing, and biomarker identification.
    • Represents a powerful tool for creating more predictive and physiologically relevant in vitro models.