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Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

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Systemic amyloidosis presenting with glans penis involvement.

Angel Fernandez-Flores¹, Jorge A Castañón-González, Brenda Guerrero-Ramos

¹Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.

Journal of Cutaneous Pathology

|August 6, 2014

Summary

Systemic amyloidosis, a rare condition, can manifest initially as a penile ulcer. This presentation, involving lambda light chain amyloidosis, was observed in two patients with associated nail abnormalities.

Keywords:

genital amyloidosis penile amyloidosis urethral amyloidosis

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Area of Science:

Urology
Nephrology
Hematology

Background:

Penile amyloidosis is typically a manifestation of primary cutaneous amyloidosis.
Systemic amyloidosis rarely presents with penile involvement as an initial symptom.

Observation:

Two patients presented with a penile glans ulcer as their first clinical manifestation.
Immunohistochemical analysis confirmed lambda light chain type amyloid deposits.

Findings:

The penile ulcer was the initial sign leading to the diagnosis of systemic amyloidosis.
Both patients exhibited nail dystrophy, including onycholysis, trachyonychia, and onychoschizia.

Implications:

This case series highlights a previously unreported initial presentation of systemic amyloidosis.
Early recognition of penile ulcers as a potential sign of systemic amyloidosis is crucial for timely diagnosis and management.