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Severe parechovirus infection in Norwegian infants

Marius K Skram1, Lars H Skanke, Sidsel Krokstad

  • 1From the *Department of Pediatrics, Oslo University Hospital, Oslo; †Department of Pediatrics; ‡Department of Medical Microbiology, St. Olavs University Hospital; §Department of Medicine, Norwegian University of Science and Technology, Trondheim; and ¶Department of Pediatrics, Ålesund Hospital, Ålesund, Norway.

The Pediatric Infectious Disease Journal
|August 6, 2014
PubMed

Insights

A novel Human parechovirus genotype 3 (HPeV-3) strain caused severe illness, including sepsis-like disease and meningoencephalitis, in 15 Norwegian infants. Most infants recovered fully within weeks, indicating a generally favorable prognosis for this new HPeV-3 strain.

Area of Science:

  • Virology
  • Pediatric Infectious Diseases
  • Genetics

Background:

  • Human parechovirus genotype 3 (HPeV-3) is associated with severe illness in infants.
  • Infants younger than 3 months are particularly vulnerable to HPeV-3 complications such as meningoencephalitis and sepsis-like disease.

Purpose of the Study:

  • To characterize the clinical and phylogenetic features of HPeV-3 infections in Norwegian infants.
  • To identify and analyze a potentially new HPeV-3 strain.

Main Methods:

  • Retrospective analysis of 15 infants diagnosed with HPeV-3 infections across three Norwegian hospitals.
  • Phylogenetic analysis of the viral protein (VP)3/VP1 region to determine genetic relatedness of isolates.

Main Results:

  • A novel HPeV-3 strain was identified, closely related among all isolates.
  • Eleven infants presented with sepsis-like disease, and 10 had meningoencephalitis.
  • Fourteen of 15 infants recovered within 1-3 weeks; one showed initial MRI abnormalities but had normal psychomotor status at 1 year.

Conclusions:

  • A new HPeV-3 strain was responsible for a cluster of sepsis-like disease and meningoencephalitis cases in Norwegian infants.
  • The majority of affected infants demonstrated a good recovery, with most regaining normal health within weeks.
Abstract

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