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Updated: Apr 26, 2026

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
Published on: August 1, 2013
MHC basis of T cell-dependent heterologous immunity to arenaviruses
Keith A Daniels1, Steven D Hatfield1, Raymond M Welsh1
1Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Abstract:
Having a history of infection with one pathogen may sometimes provide a level of T cell-dependent protective heterologous immunity to another pathogen. This immunity was initially thought due to cross-reactive T cell epitopes, but recent work has suggested that such protective immunity can be initiated nonspecifically by the action of cytokines on memory T cells. We retested this concept using two small and well-defined arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PV), and found that heterologous immunity in these systems was indeed linked to T cell epitopes and the major histocompatibility complex.
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