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Related Concept Videos

Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

25
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
25
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Related Experiment Video

Updated: Apr 26, 2026

Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study
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Stiff person syndrome: a case report.

Patricia A Kelly1, Carolyn Kuberski1

  • 1Texas Health Presbyterian Hospital Dallas.

Clinical Journal of Oncology Nursing
|August 6, 2014
PubMed
Summary

A patient with common breast cancer developed stiff person syndrome, a rare autoimmune disorder causing severe pain, stiffness, and cognitive decline. Early diagnosis and treatment are crucial for managing this malignancy-associated condition.

Area of Science:

  • Neurology
  • Oncology
  • Immunology

Background:

  • Stiff person syndrome (SPS) is a rare autoimmune neurological disorder.
  • It is characterized by fluctuating muscle rigidity and painful spasms.
  • SPS can be associated with malignancies, including breast cancer.

Observation:

  • A case report details a patient diagnosed with a common breast cancer subtype.
  • The patient presented with an unusual neurologic syndrome: severe pain, progressive stiffness, and cognitive/functional decline.
  • These symptoms were indicative of stiff person syndrome.

Findings:

  • The case highlights the co-occurrence of breast cancer and stiff person syndrome.
  • It underscores the importance of recognizing neurologic manifestations in cancer patients.
Keywords:
auto-immunemalignancyneurologicalparaneoplastic syndromestiff person

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  • The article discusses the pathogenesis and treatment strategies for malignancy-associated SPS.

    • Implications:

    • This report emphasizes the need for heightened awareness of stiff person syndrome in oncology settings.
    • It suggests potential diagnostic and therapeutic avenues for managing this rare but treatable condition.
    • Further research into the link between malignancy and autoimmune neurological disorders is warranted.