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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Related Experiment Video

Updated: Apr 26, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Gene and stem cell therapy for diabetes.

Roy Y Calne, Mohamed A Ghoneim, K O Lee

    Clinical Transplants
    |August 7, 2014
    PubMed
    Summary

    Advancing gene and stem cell therapy for diabetes involves engineering insulin-producing cells. Further research is needed to ensure glucose responsiveness and long-term efficacy for clinical applications.

    Area of Science:

    • Regenerative Medicine
    • Gene Therapy
    • Endocrinology

    Background:

    • Gene and stem cell therapy research has spanned over two decades with limited clinical translation.
    • Recent breakthroughs in stem cell biology and gene therapy are beginning to address previous challenges.

    Purpose of the Study:

    • To observe the potential of bone marrow mesenchymal stem cells for diabetes treatment.
    • To investigate the engineering of human insulin gene into viral vectors for therapeutic use.

    Main Methods:

    • Culturing bone marrow mesenchymal stem cells to induce insulin production.
    • Utilizing lentivirus (Lenti) and adeno-associated virus (AA) for human insulin gene delivery.

    Main Results:

    • A small percentage of cultured mesenchymal stem cells demonstrated insulin-producing capabilities.

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  • The study highlights the feasibility of gene engineering for enhanced cellular function.

    • Conclusions:

    • Clinical applications for gene and stem cell therapy in diabetes are still several years away.
    • Key challenges include scaling up insulin-secreting cell production and ensuring appropriate glucose-responsive insulin secretion.
    • Long-term efficacy and durability of therapeutic effects remain critical considerations for patient benefit.