[Proinflammatory cytokines and C-reactive protein in urine: prospects for diagnosis in patients with chronic...

The study involved 85 patients with chronic pyelonephritis in age from 26 to 62 years. All patients determined C-reactive protein (CRP), interleukin 6 and tumor necrosis factor-alpha in the blood and urine by standard techniques. With the simultaneous study of CRP in the blood and urine of patients with chronic pyelonephritis detected high levels of this biomarker in the urine, which is several times higher than its indicators levels in blood. When studying the levels of proinflammatory cytokines, which are the main inducers excretion of CRP, we found that the increase in their concentration in urine was more pronounced than in the blood, which confirms the opinion that CRP can be synthesized in inflammation focus by lymphocytes, macrophages and endothelial. Studying the levels of cytokines and C-reactive protein in the urine can be used to assess the severity of inflammatory changes in the kidney and to monitor the effectiveness of anti-inflammatory therapy.