The convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancer

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Updated: Apr 26, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Huy Q Ta1, Daniel Gioeli2

  • 1Department of MicrobiologyImmunology, and Cancer BiologyUVA Cancer CenterUniversity of Virginia, PO Box 800734, Charlottesville, Virginia 22908, USA.

Endocrine-Related Cancer
|August 7, 2014
PubMed

Insights

Castration-resistant prostate cancer (PCa) relies on the androgen receptor (AR). DNA damage response pathways interact with AR signaling, influencing PCa progression and treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer (PCa) progression to castration-resistance is linked to androgen receptor (AR) signaling.
  • Current therapies target AR signaling but do not fully account for its complex interactions.
  • Cancer arises from genetic alterations, with DNA damage response (DDR) pathways crucial for maintaining genomic integrity.

Purpose of the Study:

  • To review the intricate relationship between checkpoint signaling pathways and AR activity in prostate cancer.
  • To elucidate how DDR proteins regulate AR function and vice versa.
  • To identify current knowledge gaps and future research directions in this field.

Main Methods:

  • Literature review focusing on the intersection of AR signaling and DNA damage response in PCa.
  • Synthesis of existing research on how checkpoint signaling components influence AR.
  • Analysis of the impact of AR on DNA damage response proteins.

Main Results:

  • The androgen receptor (AR) is not an isolated entity but integrates with various cell-signaling proteins.
  • Components of checkpoint signaling pathways interact with and affect AR activity.
  • AR signaling pathways are influenced by DNA damage response proteins.

Conclusions:

  • Understanding the interplay between checkpoint signaling and AR is critical for advancing castration-resistant prostate cancer treatment.
  • Further research is needed to fully delineate these interactions and their therapeutic implications.
Keywords:
androgen receptorcell signalingchemotherapyendocrine therapy resistanceoncogene

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