Related Experiment Video
Updated: Apr 26, 2026
Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Sensitivity and specificity of red cell distribution width in diagnosing acute mesenteric ischemia in patients with
Abdullah Kisaoglu1, Atif Bayramoglu, Bunyami Ozogul
1Department of General Surgery, School of Medicine, Ataturk University, 25070, Erzurum, Turkey, kisaoglu.a@gmail.com.
Background:
We investigated the utility of the red cell distribution width (RDW) in diagnosing acute mesenteric ischemia (AMI) in patients with abdominal pain.
Methods:
The patients were divided into two groups in this retrospective case-control study: patients with AMI and patients with abdominal pain who did not require urgent surgery. Venous blood was collected from the patients upon admission to the emergency department, and abdominal computed tomography angiography was performed. The RDW and hematological and biochemical parameters of the groups were compared. The primary outcome was AMI among the patients with abdominal pain. The secondary outcome was mortality, complaint period, and size of ischemia/necrosis among the AMI patients.
Results:
The RDW, white blood cell lactate dehydrogenase, and blood urea nitrogen of the patients with AMI were significantly different from those of the control group. When the average RDW (15.04 %) of the patients with AMI was used as a cut-off value, the sensitivity, specificity, positive likelihood ratio (+LR), and negative likelihood (-LR) were 40.8 %, 81.2 %, 2.17, and 0.73, respectively. When patients with AMI and anemia were included in the group, the sensitivity and specificity values did not change. There was no relation between the RDW and mortality, size of the ischemia/necrosis, and complaint period. Furthermore, there was no significant difference in the average RDW between the patients with ischemia/necrosis in the small intestine only and those with ischemia/necrosis in the colon.
Conclusion:
The RDW on admission is of marginal help to diagnose AMI among patients with abdominal pain.
Insights
The red cell distribution width (RDW) has limited utility in diagnosing acute mesenteric ischemia (AMI) in patients presenting with abdominal pain. While RDW showed some diagnostic differences, its sensitivity was low for identifying AMI.
Area of Science:
- Medical Diagnostics
- Gastroenterology
- Emergency Medicine
Background:
- Acute mesenteric ischemia (AMI) is a critical condition requiring prompt diagnosis.
- Red cell distribution width (RDW) is an easily accessible hematological parameter.
Purpose of the Study:
- To evaluate the diagnostic utility of RDW for AMI in patients with abdominal pain.
- To assess the correlation of RDW with AMI severity and patient outcomes.
Main Methods:
- Retrospective case-control study comparing AMI patients with non-surgical abdominal pain patients.
- Analysis of RDW, hematological, and biochemical parameters from blood samples.
- Abdominal computed tomography angiography used for diagnosis.
Main Results:
- RDW was significantly different between AMI and control groups (p<0.05).
- At a cut-off of 15.04%, RDW had 40.8% sensitivity and 81.2% specificity for AMI.
- RDW did not correlate with mortality, ischemia size, or complaint duration.
Conclusions:
- RDW has marginal diagnostic value for AMI in patients with abdominal pain.
- RDW's low sensitivity limits its role as a standalone diagnostic marker for AMI.
