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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
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[Hepatitis B infection in children]

Vibeke Brix Christensen1, Sannie Nordly, Mette Kjær

  • 1Gl. Strandvej 164, 3050 Humlebæk. brixchr@dadlnet.dk.

Ugeskrift for Laeger
|August 7, 2014
PubMed

Chronic hepatitis B (HBV) infection is seen in 400 million persons worldwide. HBV is transmitted vertically or horizontally by infected blood and body fluids. An effective vaccine exists. Most children develop a chronic HBV infection if infected early in life. They are often in an immune-tolerant phase with no indication for antiviral treatment. Antiviral treatment with interferon or a nucleotide analogue is a possibility if the HBV infected child develops into a phase of immune activation. HBV infection can lead to liver cirrhosis and hepatocellular carcinoma.

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