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Updated: Apr 26, 2026

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
Published on: November 11, 2013
[Long-term treatment with opioid drugs]
1Palliativt Afsnit, Rigshospitalet, Blegdamsvej 9, 2100 København Ø. rh12244@rh.regionh.dk.
Abstract:
It is well established that morphine and other opioid drugs in both men and women exert a pronounced effect on the gonads, causing hypogonadotroph hypogonadism. The thyroid function seems unimpaired. Only a small number of studies have addressed the effects of opioids on the adrenocortical function. They strongly suggest that opioids may cause adrenocortical insufficiency - even presenting as severe and life-threatening hypoadrenalism. At present a substantial number of patients are on long-term treatment with opioids, making the above findings relevant in daily clinical practice.
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