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High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
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Outer membrane inflammatory protein A, a new virulence factor involved in the pathogenesis of Helicobacter pylori

Jinyong Zhang1, Jiajun Qian, Xiaoli Zhang

  • 1Department of Microbiology and Biochemical Pharmacy, National Engineering Research Center of Immunological Products, College of Pharmacy, Third Military Medical University, Chongqing, 400038, People's Republic of China.

Molecular Biology Reports
|August 7, 2014
PubMed

Insights

Outer membrane inflammatory protein A (OipA) is a unique protein in Helicobacter pylori. This review details OipA

Area of Science:

  • Microbiology
  • Molecular Biology
  • Pathogenesis

Background:

  • Outer membrane proteins (OMPs) are crucial in gram-negative bacteria, mitochondria, and chloroplasts.
  • Helicobacter pylori (H. pylori), a gastrointestinal pathogen, possesses various OMPs.
  • OipA, encoded by hopH, is a unique, differentially expressed OMP in H. pylori.

Purpose of the Study:

  • To review recent studies on Outer membrane inflammatory protein A (OipA).
  • To elucidate the functions and biological significance of OipA in H. pylori.

Main Methods:

  • Literature review of studies on OipA.
  • Analysis of OipA's role in H. pylori.

Main Results:

  • OipA is directly linked to H. pylori colonization.
  • OipA influences H. pylori pathogenesis and disease outcomes.

Conclusions:

  • OipA is a key virulence factor in H. pylori.
  • Further research on OipA's functions is warranted.

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