Related Experiment Video
Updated: Apr 26, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Hypercalcaemia can be the only initial symptom of sarcoidosis]
Thorbjørn Hermanrud1, Julie Hjortsø Janner, Ida Elisabeth Steffensen
1Amerikavej 6, 4. th., 1756 København V. thermanrud@gmail.com.
Abstract:
Sarcoidosis is an ordinary systemic inflammatory disease that can affect many organs. It is characterized by development of non-necrotizing granulomas. It commonly affects lungs (80%) while hypercalcaemia is found in 5% and reflects an activation of T-cells within the granulomas that causes an overproduction of 1,25-dihydroxyvitamin D3. We describe a case where hypercalcaemia was the only symptom in a patient with extrapulmonary sarcoidosis, and the investigation was misled by different serologic findings though PET-CT showed fludeoxyglucose uptake in the biceps femoris muscles. The diagnosis was made after a biopsy.
Related Concept Videos
Pericarditis II: Clinical Features and Diagnostic Tests
Graves Disease II: Pathophysiology
Skeleton and Calcium Homeostasis
Chronic Kidney Disease II: Clinical Manifestations
Diabetic Ketoacidosis l: Introduction
Graves' Disease I: Introduction
