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Updated: Apr 26, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Understanding the thermal [1s,5s] hydrogen shift isomerization of ocimene
Eduardo Chamorro1, Pablo Ruiz, Jairo Quijano
1Departamento de Ciencias Químicas, Universidad Andres Bello, Avenida Republica 275, 8370146, Santiago, Chile, echamorro@unab.cl.
Abstract:
α-Ocimene, β-ocimenes and alloocimenes are isomeric monoterpenes occurring naturally as oils within several plants and fruits. These thermally unstable compounds are employed in the pharmaceutical and fine-chemicals industries due to their natural plant defense properties and pleasant odors. In this work, and in the context of a recent revival in attention on the subject, we provide new theoretical insights concerning the nature of the electronic reorganization driving the decomposition of cis-β-ocimene to alloocimene. Our findings support the experimental proposal of a rearrangement via a six-membered cyclic transition state in a one-step concerted and highly synchronic process.
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