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Updated: Apr 26, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Are cognitive interventions for multiple sclerosis effective and feasible?

Rosana Magalhães¹, Jorge Alves¹, Roger E Thomas²

¹Neuropsychophysiology Laboratory, CIPsi, School of Psychology, University of Minho, Braga, Portugal.

Restorative Neurology and Neuroscience

|August 7, 2014

Summary

Cognitive interventions show no significant effects on cognition or mood in Multiple Sclerosis (MS) patients, despite high adherence. Further research is needed to establish efficacy and cost-effectiveness for MS cognitive health.

Keywords:

Rehabilitation feasibility meta-analysis multiple sclerosis systematic review

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A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

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Published on: December 26, 2015

Area of Science:

Neuroscience
Rehabilitation Medicine

Background:

Multiple Sclerosis (MS) frequently causes cognitive impairments, impacting patient productivity and quality of life.
Cognitive interventions are explored as adjunctive therapies, but their effectiveness in MS remains debated.

Purpose of the Study:

To systematically review and meta-analyze the efficacy of cognitive interventions in patients with Multiple Sclerosis (MS).
To address limitations of previous meta-analyses by focusing exclusively on high-quality Randomized Clinical Trials (RCTs).

Main Methods:

A systematic search of multiple databases was performed to identify relevant Randomized Clinical Trials (RCTs).
Studies were selected based on low risk of bias to ensure methodological rigor.

Main Results:

Five studies, involving 139 participants, met the inclusion criteria.
No statistically significant evidence of intervention effects on cognition or mood was found at post-intervention or follow-up assessments.
High rates of intervention completion and adherence were observed.

Conclusions:

This meta-analysis, the first to exclusively include low-bias RCTs in MS, found no current evidence for cognitive intervention efficacy.
Research on the efficacy, cost-effectiveness, and feasibility of cognitive interventions in MS is nascent.
Despite promising adherence, further high-quality research is warranted, with recommendations for improved study design provided.