Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

HbA1c variability as an independent risk factor for diabetic retinopathy: results from a screening program.

Acta diabetologica·2026

Same author

Voretigene Neparvovec Gene Therapy in Clinical Practice: A 12-Month, Single-Center, In-Depth Analysis of Beneficial and Adverse Drug Effects.

Translational vision science & technology·2026

Same author

Effects of New P2X7R Antagonists on Retinal Inflammatory Degenerative Conditions.

Inflammation·2026

Same author

Integrating Psychiatric, Psychotherapeutic, and Nursing Care in Intranasal Esketamine for Treatment-Resistant Depression.

Journal of clinical medicine·2026

Same author

Intraocular pressure and corneal biomechanics in patients affected by myotonic dystrophy type 1.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026

Same author

Intravitreal Dexamethasone Implant in Retinal Vein Occlusion: A Pilot Study Exploring Baseline Ocular and Circulating Biomarkers.

International journal of molecular sciences·2026

Search research articles

Related Experiment Video

Updated: Apr 26, 2026

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

Macular function and morphologic features in juvenile stargardt disease: longitudinal study.

Francesco Testa¹, Paolo Melillo¹, Valentina Di Iorio¹

¹Multidisciplinary Department of Medical, Surgical, and Dental Sciences, Eye Clinic, Second University of Naples, Naples, Italy.

|August 7, 2014

Summary

Stargardt disease patients show progressive vision loss and macular changes. Microperimetry and OCT are crucial for monitoring disease progression and designing future gene therapy trials.

More Related Videos

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Published on: March 11, 2016

Related Experiment Videos

Last Updated: Apr 26, 2026

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

Published on: March 11, 2016

Area of Science:

Ophthalmology
Genetics
Retinal Dystrophies

Background:

Stargardt disease is a common inherited retinal dystrophy.
Early diagnosis and monitoring are essential for managing disease progression.

Purpose of the Study:

To evaluate disease progression in a cohort of patients diagnosed with Stargardt disease.
To assess the utility of microperimetry and optical coherence tomography in monitoring Stargardt disease.

Main Methods:

A longitudinal cohort study of 56 patients with Stargardt disease.
Evaluations included best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT).
Follow-up duration was a median of 2 years.

Main Results:

Progressive decline in BCVA and macular sensitivity was observed.
Optical coherence tomography revealed significant changes in the retinal pigment epithelium and inner/outer segment junction.
Retinal pigment epithelium lesion area increased significantly over time.

Conclusions:

Microperimetry and OCT are vital tools for monitoring Stargardt disease progression.
Quantifying visual decline and macular changes aids in evaluating disease.
These findings are important for designing future clinical trials for Stargardt disease gene therapy.