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Does tramadol affect coagulation status of patients with malignancy?
Ayten Bilir1, Meltem Olga Akay2, Dilek Ceyhan1
1Department of Anaesthesiology and Reanimation, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey.
Indian Journal of Pharmacology
|August 7, 2014
Summary
Tramadol was found to slow blood clotting in women with gynecologic cancers. This study shows tramadol impacts hemostasis in a concentration-dependent manner in vitro.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- Gynecologic malignancies can affect hemostasis.
- Understanding drug effects on blood coagulation is crucial for patient management.
Purpose of the Study:
- To investigate the in vitro effects of tramadol on the coagulation status of women with gynecologic malignancies.
Main Methods:
- Whole-blood samples from 21 patients were analyzed using rotational thromboelastometry (ROTEM).
- Samples were spiked ex vivo with tramadol at concentrations of 2 or 6 μl/ml.
- Key hemostasis parameters including clotting time (CT), clot formation time (CFT), and maximum clot formation (MCF) were assessed.
Main Results:
- Tramadol at 6 μl/ml significantly prolonged clotting time (CT) and clot formation time (CFT) compared to baseline (P < 0.05 and P < 0.01, respectively).
- No significant differences in maximum clot formation (MCF) were observed.
- Tramadol demonstrated a concentration-dependent effect, slowing blood clotting.
Conclusions:
- Tramadol impairs hemostasis in a concentration-dependent manner in the whole blood of women with gynecologic malignancies.
- These in vitro findings suggest potential implications for managing coagulation in patients receiving tramadol.
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