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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Cherubism: A rare case report.

Manpreet Kaur1, Sonali Shah1, Prashant Babaji2

  • 1Department of Oral Pathology, Raj Rajeswari Dental College, Udaipur, Rajasthan, India.

Journal of Natural Science, Biology, and Medicine
|August 7, 2014
PubMed
Summary
This summary is machine-generated.

Cherubism is a rare genetic disorder causing jaw malformations in children, typically before age 5. This condition often resolves after puberty but requires understanding for proper management.

Keywords:
Cherubismchildhood diseasegiant cell lesionjaw growthmalocclusion

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Area of Science:

  • Genetics and developmental biology
  • Pediatric dentistry and craniofacial anomalies

Background:

  • Cherubism is a rare, benign, autosomal dominant disorder.
  • Characterized by progressive, symmetrical enlargement of the jawbones.

Observation:

  • Typically presents before age 5 years.
  • Leads to significant dental and facial abnormalities.
  • Can cause psychological distress due to disfigurement.

Findings:

  • Jaw enlargement due to fibrous dysplasia.
  • Associated with unerupted or displaced teeth.
  • Spontaneous regression observed after puberty.

Implications:

  • Early diagnosis and monitoring are crucial.
  • Management focuses on preventing complications and addressing aesthetic concerns.
  • Further research needed to understand genetic mechanisms and long-term outcomes.