MRI tracking stem cells transplantation for coronary heart disease
Xi Lu1, Rui Xia2, Bing Zhang3
1Xi Lu, Molecular Imaging Laboratory, Department of Radiology, West China Hospital, Sichuan University, No.1, Ke Yuan Road 4, Gao Xin District, Chengdu, 610041, Sichuan, China.
Insights
Cardiac magnetic resonance imaging (MRI) offers a non-invasive method to track stem cells in cardiovascular disease treatment. This technique aids in understanding stem cell therapy
Area of Science:
- Regenerative Medicine
- Cardiovascular Imaging
- Biomedical Engineering
Background:
- Cardiovascular disease (CVD) is the primary global cause of mortality.
- Stem cell transplantation is an emerging treatment for CVD, promoting cardiac tissue repair and reducing mortality.
- Cardiac magnetic resonance imaging (MRI) is a non-invasive technique for assessing cardiac function and anatomy.
Purpose of the Study:
- To review the advantages and disadvantages of cardiac MRI in stem cell transplantation.
- To discuss the clinical translation of cardiac MRI for stem cell therapy.
- To highlight MRI's role in studying stem cell mechanisms in cardiac repair.
Main Methods:
- Literature review of cross-sectional and prospective studies (2001-2013).
- Data sourced from statistical reports, PubMed, MEDLINE, Google Scholar, and medical/radiological journals.
- Inclusion of both human and animal studies.
Main Results:
- Cardiac MRI provides high spatial/temporal resolution for imaging.
- It offers a safe, non-invasive method to assess stem cell migration, engraftment, differentiation, and survival.
- MRI can visualize anatomical changes and myocardial dysfunction post-transplantation.
Conclusions:
- Cardiac MRI is a valuable tool for monitoring stem cell therapy in cardiovascular disease.
- The technique facilitates understanding of cell behavior and therapeutic efficacy.
- Further translation of cardiac MRI into clinical practice is warranted.
Unlabelled:
Cardiovascular disease is the leading cause of mortality worldwide. Stem cell transplantation has become a new treatment option for cardiovascular disease because the stem cells are able to migrate to damaged cardiac tissue, repair the myocardial infarction area and ultimately reduce the role of the infarct-related mortality. Cardiac magnetic resonance imaging (MRI) is a new robust non-invasive imaging technique that can detect anatomical information and myocardial dysfunction, study the mechanism of stem cells therapy with superb spatial/temporal resolution, relatively safe contrast material and lack of radiation. This review describes the advantages and disadvantages of cardiac MRI applied in stem cells transplantation and discusses how to translate this technique into clinical therapy. Sources of Data/Study Selection: Data from cross-sectional and prospective studies published between the years 2001-2013 on the topic were included. Data searches included both human and animal studies.
Data Extraction:
The data was extracted from online resources of statistic reports, Pub med, THE MEDLINE, Google Scholar, Medical and Radiological journals.
Conclusion:
MRI is an appealing technique for cell trafficking depicting engraftment, differentiation and survival.
