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Updated: Apr 26, 2026
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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
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Immunoglobulin genes implicated in glioma risk
Janardan P Pandey1, Navtej Kaur1, Sandra Costa2
1Department of Microbiology and Immunology; Medical University of South Carolina; Charleston, SC USA.
Oncoimmunology
|August 7, 2014
Summary
The immunoglobulin heavy chain gamma (IGHG) GM 3 allele may increase glioma risk. Individuals with GM 3 or GM 3/17 genotypes showed a significantly higher likelihood of developing glioma, particularly high-grade astrocytoma.
Area of Science:
- Immunogenetics
- Neuro-oncology
- Infectious disease
Background:
- Gliomagenesis involves genetic and environmental factors.
- The role of immunoglobulin heavy chain gamma (IGHG) in glioma risk is unexplored.
- Cytomegalovirus (CMV) immunoevasion strategies linked to IGHG-encoded gamma marker (GM) allotypes suggest a potential role in gliomagenesis.
Purpose of the Study:
- To investigate the association between IGHG GM allotypes and glioma risk.
- To determine if specific GM alleles (GM 3 and GM 17) are risk factors for glioma development.
Main Methods:
- Genotyping of IGHG GM alleles (GM 3 and GM 17) in 120 glioma patients and 133 controls using TaqMan® assay.
- Unconditional multivariate logistic regression analysis to assess genotype-glioma risk associations, adjusted for confounders.
Main Results:
- GM 3 homozygotes had over twice the risk of glioma compared to GM 17 homozygotes.
- GM 3/17 heterozygotes had over three times the risk of glioma.
- GM 3 allele and combined GM 3/GM 3/17 genotypes were associated with increased risk for high-grade astrocytoma (grades III-IV).
Conclusions:
- The GM 3 allele is a potential risk factor for glioma development.
- Findings suggest GM 3 may influence glioma risk by modulating immunity to cytomegalovirus.
- Further research into immunogenetic factors in gliomagenesis is warranted.
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