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Galectins in epithelial functions.

Mireille Viguier1, Tamara Advedissian1, Delphine Delacour1

  • 1Institut Jacques Monod Umr 7592 Cnrs-Université Paris Diderot ; Paris, France.

Tissue Barriers
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Summary
This summary is machine-generated.

Galectins, a family of animal lectins, regulate epithelial cells. This review explores their diverse roles in biological processes like homeostasis and tumor progression.

Keywords:
adhesioncell junctionsepitheliagalectinsglycosylationmigrationpolarity

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Galectins are animal lectins with diverse intracellular and extracellular functions.
  • They play roles in epithelial homeostasis and tumor progression.
  • Galectins are found in cytoplasm, nucleus, membranes, and extracellular matrix.

Purpose of the Study:

  • To review recent progress in understanding Galectins.
  • To define Galectin specificities and mechanisms of action in epithelial cells.
  • To discuss physiological, cellular, and molecular aspects of Galectin specificities.

Main Methods:

  • Literature review of current studies on Galectins.
  • Analysis of Galectin roles in cell-cell and cell-matrix adhesion.
  • Examination of Galectin involvement in cellular polarity and motility.

Main Results:

  • Galectins exhibit varied intracellular and extracellular activities.
  • They are implicated in maintaining epithelial homeostasis.
  • Galectins contribute to tumor progression and cell regulation.

Conclusions:

  • Galectins are key regulators of epithelial cell functions.
  • Understanding Galectin specificities is crucial for their roles in health and disease.
  • Further research is needed to fully elucidate Galectin mechanisms.