Augmented plasma adiponectin after prolonged fasting during ramadan in men

Area of Science:

• Metabolic Health
• Endocrinology
• Nutritional Science

Background:

• Intermittent fasting during Ramadan significantly alters metabolism and energy expenditure.
• Adiponectin and TNF-α are key peptides influencing insulin sensitivity and glucose metabolism.

Purpose of the Study:

• To investigate the effect of Ramadan fasting on serum adiponectin and TNF-α levels.
• To assess changes in insulin sensitivity and glucose metabolism markers.

Main Methods:

• Seventy healthy men (age ≥30) with ≥3 type 2 diabetes risk factors were studied.
• Serum adiponectin, TNF-α, lipid profile, anthropometric indices, and plasma glucose were measured.
• Enzyme-linked Immunosorbent Assay and paired t-test were used for analysis.

Main Results:

• Ramadan fasting led to significant increases in serum adiponectin, fasting glucose, and triglycerides.
• Body mass index decreased significantly during fasting.
• No significant change was observed in serum TNF-α levels.

Conclusions:

• Ramadan fasting augmented adiponectin levels, potentially improving metabolic stress.
• Findings suggest a benefit for insulin resistance in men predisposed to type 2 diabetes.