Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

26
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
26
Diabetic Neuropathy01:22

Diabetic Neuropathy

42
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
42
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

12
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
12
Diabetic Retinopathy01:27

Diabetic Retinopathy

48
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
48
Diabetic Nephropathy01:28

Diabetic Nephropathy

25
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
25
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.5K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geographical variation in <i>Tylencholaimus mirabilis</i> (Nematoda: Tylencholaiminae) evidence from South African and Indian populations.

Zootaxa·2026
Same author

Recurrent MBTPS2 variant c.970+5G>A in IFAP syndrome: a mutational hotspot.

Human genome variation·2026
Same author

Skin-Only Closure Versus Bogota Bag: A Comparative Study of Complete Fascial Approximation Rates.

Cureus·2026
Same author

HOXD12 a candidate gene for a novel form of synpolydactyly.

Bone·2026
Same author

Concept of Urolithiasis in Unani Medicine: Traditional Approaches and Contemporary Insights.

Advances in mind-body medicine·2026
Same author

Advanced fault diagnosis in milling cutting tools using vision transformers with semi-supervised learning and uncertainty quantification.

Scientific reports·2025

Related Experiment Video

Updated: Apr 26, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

4.4K

Risk factors for diabetic foot ulcer.

Wasim Ahmad, Ishtiaq Ali Khan, Salma Ghaffar

    Journal of Ayub Medical College, Abbottabad : JAMC
    |August 8, 2014
    PubMed
    Summary

    Diabetic foot ulcers are linked to neuropathy, peripheral arterial disease, and diabetes duration. Addressing these risk factors is crucial for patient education and improved outcomes in diabetes management.

    Area of Science:

    • Diabetology
    • Vascular Medicine
    • Infectious Diseases

    Background:

    • Diabetic foot is a significant complication of diabetes mellitus.
    • Multiple risk factors contribute to its development.
    • Understanding these factors is key to prevention and treatment.

    Purpose of the Study:

    • To identify and analyze the primary risk factors for diabetic foot ulceration.
    • To correlate these risk factors with disease severity and patient outcomes.

    Main Methods:

    • A cohort of 196 diabetic foot patients was studied.
    • Data collected included patient history, clinical findings, and investigations.
    • Exclusion criteria included non-consent, established gangrene, and significant comorbidities.

    More Related Videos

    A Simplified Technique for Producing an Ischemic Wound Model
    12:00

    A Simplified Technique for Producing an Ischemic Wound Model

    Published on: May 2, 2012

    17.0K
    Protocol to Create Chronic Wounds in Diabetic Mice
    06:55

    Protocol to Create Chronic Wounds in Diabetic Mice

    Published on: September 25, 2019

    20.8K

    Related Experiment Videos

    Last Updated: Apr 26, 2026

    Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
    04:09

    Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

    Published on: March 3, 2023

    4.4K
    A Simplified Technique for Producing an Ischemic Wound Model
    12:00

    A Simplified Technique for Producing an Ischemic Wound Model

    Published on: May 2, 2012

    17.0K
    Protocol to Create Chronic Wounds in Diabetic Mice
    06:55

    Protocol to Create Chronic Wounds in Diabetic Mice

    Published on: September 25, 2019

    20.8K

    Main Results:

    • The majority of patients (80.1%) were male, with 74.48% aged 40-70.
    • Diabetes duration exceeded 5 years in 91.3% of patients.
    • Key findings included high prevalence of neuropathy (51%), peripheral arterial disease (62.8%), infection (85.7%), and osteomyelitis (42.9%).

    Conclusions:

    • Peripheral neuropathy, peripheral arterial disease, and duration of diabetes are major risk factors.
    • Underlying osteomyelitis significantly impacts outcomes.
    • Patient education focusing on these factors is essential for managing diabetic foot complications.