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Matrix metalloproteinase inhibitors: a patent review (2011 - 2013)
Nian-Guang Li1, Yu-Ping Tang, Jin-Ao Duan
1Nanjing University of Chinese Medicine, National and Local Collaborative Engeering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine , 138 Xianlin Road, Nanjing 210023, Jiangsu , China +86 25 85811916 ; +86 25 85811916 ; yupingtang@njutcm.edu.cn.
Introduction:
The MMPs are involved in tissue remodeling. An imbalance between the inhibition and activation of MMPs results in excessive degradation of the extracellular matrix, which leads to some diseases including cancer, rheumatoid arthritis, osteoarthritis, heart disease and neurodegenerative diseases such as stroke. In this review, recent advances in the research of MMP inhibitors are reviewed.
Areas Covered:
This updated review summarized new patents on MMP inhibitors within January 2011 - December 2013.
Expert Opinion:
This review gives the latest development in the area of MMP inhibitors, which aim to treat disease processes associated with the MMPs. Structure-based design techniques have been used successfully in the search of selective MMP inhibitors, and these inhibitors can also be derived from natural products. Furthermore, imaging 'in vivo' technologies have been developed in order to follow the drug distribution to the targeted tissues, and to quantify the drug efficiency.
Insights
Matrix metalloproteinase (MMP) inhibitors are crucial for treating diseases caused by excessive extracellular matrix degradation. This review covers recent advancements in MMP inhibitor research and development.
Area of Science:
- Biochemistry
- Pharmacology
- Drug Discovery
Background:
- Matrix metalloproteinases (MMPs) play a key role in tissue remodeling.
- Imbalances in MMP activity lead to excessive extracellular matrix degradation, contributing to diseases like cancer, arthritis, and stroke.
- MMP inhibitors are investigated to counteract these pathological processes.
Purpose of the Study:
- To review recent advancements in the research of matrix metalloproteinase (MMP) inhibitors.
- To summarize new patents related to MMP inhibitors from January 2011 to December 2013.
Main Methods:
- Literature review of patents and research publications on MMP inhibitors.
- Analysis of structure-based design techniques for selective MMP inhibitors.
- Review of natural product-derived MMP inhibitors.
- Examination of in vivo imaging technologies for drug distribution and efficacy assessment.
Main Results:
- Structure-based design has proven successful in developing selective MMP inhibitors.
- Natural products represent a viable source for MMP inhibitor discovery.
- In vivo imaging technologies are advancing for monitoring drug delivery and effectiveness.
Conclusions:
- The review highlights the latest developments in MMP inhibitor research for treating MMP-associated diseases.
- Selective MMP inhibitors can be designed using structure-based approaches and derived from natural sources.
- In vivo imaging aids in evaluating drug distribution and efficacy in targeted tissues.
