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Updated: Apr 26, 2026
Bone Conditioned Medium: Preparation and Bioassay
Published on: July 8, 2015
Effects of self-blood on the molding process of polymethyl methacrylate bone cement
Ying-Jun Guo1, Lin Nie, Wen Zhang
1Department of Orthopaedic Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
Objective:
To evaluate whether the self-blood has influence on the molding process of polymethyl methacrylate (PMMA) bone cement, and to make sure whether it is valuable for the clinical practice.
Methods:
An in vitro study was performed to evaluate the prolonging-effect of self-blood on PMMA bone cement. The effect of prolonging was evaluated by the dough time (TD) and operable time (TO). Moreover, hardness test, squeezing value test and peak temperature test were also conducted to complete the evaluation of this program.
Results:
The self-blood, especially the plasma, could greatly prolong the handling time of PMMA bone cement without affecting its basic characteristics including hardness, leakage level and peak temperature. On the other hand, we found that in some abnormal conditions, for example with hyperlipemia, self-blood though can also prolong the handling time, would cause some side-effects.
Conclusion:
We report a new effective way to prolong the handling time of PMMA bone cement by adding moderate amount of self-blood. But "individualized medicine" should be noticed because some abnormal conditions like hyperlipemia would cause undesired side-effects.
Insights
Adding autologous blood, particularly plasma, to polymethyl methacrylate (PMMA) bone cement extends its handling time without compromising essential properties. However, caution is advised in patients with conditions like hyperlipemia due to potential adverse effects.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Medical Device Engineering
Background:
- Polymethyl methacrylate (PMMA) bone cement is widely used in orthopedic procedures.
- Optimizing the handling and setting properties of PMMA bone cement is crucial for successful clinical application.
- Prolonging the operable time of PMMA bone cement can enhance surgical precision and patient outcomes.
Purpose of the Study:
- To investigate the effect of autologous blood on the molding characteristics of PMMA bone cement.
- To determine the clinical value of using self-blood to modify PMMA bone cement properties.
- To assess if autologous blood can extend the working time of PMMA bone cement.
Main Methods:
- An in vitro study was conducted to evaluate the prolonging effect of autologous blood on PMMA bone cement.
- Dough time (TD) and operable time (TO) were measured to assess handling characteristics.
- Hardness, squeezing value, and peak temperature tests were performed to evaluate material properties.
Main Results:
- Autologous blood, specifically plasma, significantly prolonged the handling time of PMMA bone cement.
- Key characteristics such as hardness, leakage, and peak temperature remained largely unaffected.
- In certain conditions, like hyperlipemia, autologous blood prolonged handling time but introduced potential side effects.
Conclusions:
- Adding a moderate amount of autologous blood is an effective method to extend the handling time of PMMA bone cement.
- The principle of individualized medicine is important, as abnormal patient conditions can lead to adverse effects.
- This technique offers a novel approach to enhance PMMA bone cement manipulation in clinical settings.
