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Correlation between the youth cerebral infarction in different TOAST classifications and high homocysteine

Wei Zhang1, Xinan Zhang

  • 1Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China, drweizhang2014@163.com.

Cell Biochemistry and Biophysics
|August 8, 2014
PubMed

Insights

High homocysteine (Hcy) levels are linked to cerebral infarction in young adults, particularly in the large artery atherosclerosis subtype. Early intervention is crucial for better outcomes in these patients.

Area of Science:

  • Neurology
  • Biochemistry
  • Clinical Medicine

Background:

  • Cerebral infarction in young adults presents diagnostic and therapeutic challenges.
  • Elevated homocysteine (Hcy) is a potential risk factor.
  • Understanding Hcy's role across different etiological classifications is important.

Purpose of the Study:

  • To investigate the correlation between high Hcy levels and cerebral infarction in young patients.
  • To analyze Hcy's association with different TOAST classifications of cerebral infarction.
  • To guide clinical diagnosis and treatment strategies for youth cerebral infarction.

Main Methods:

  • Retrospective study comparing young cerebral infarction patients with a control group.
  • TOAST classification applied to categorize infarction subtypes.
  • Serum Hcy levels measured by enzymatic cycling.
  • NIHSS scale used for neurological deficit scoring.

Main Results:

  • Young cerebral infarction patients exhibited significantly higher serum Hcy levels than controls (P < 0.05).
  • The large artery atherosclerotic (LAA) subtype showed a significant correlation with elevated Hcy and higher NIHSS scores compared to other subtypes (P < 0.05).
  • No significant difference in Hcy levels was observed among the other four TOAST subtypes.

Conclusions:

  • High Hcy is a significant factor in the pathogenesis of youth cerebral infarction, especially related to atherosclerosis.
  • The LAA subtype associated with high Hcy tends to be more severe, necessitating clinical attention.
  • Early, cause-specific intervention and therapy are essential for managing youth cerebral infarction.

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