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Updated: Apr 26, 2026
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Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth
Published on: May 17, 2024
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Pulp treatment for extensive decay in primary teeth
Violaine Smaïl-Faugeron1, Frédéric Courson, Pierre Durieux
1Department of Dental Materials (Urb2i, EA4462), Université Paris Descartes - Sorbonne Paris Cité, 1 rue Maurice Arnoux, Montrouge, France, 75018.
The Cochrane Database of Systematic Reviews
|August 8, 2014
Summary
This review found no single superior pulp treatment for children's extensive tooth decay. Mineral trioxide aggregate (MTA) and ferric sulfate (FS) showed promise, but cost and limited evidence affect choices.
Area of Science:
- Pediatric Dentistry
- Endodontics
- Dental Materials Science
Background:
- Dental caries is a prevalent chronic disease in children worldwide.
- Pulp interventions like direct pulp capping, pulpotomy, and pulpectomy are necessary for extensive tooth decay.
- This review updates previous findings on the efficacy of different pulp treatment techniques and medicaments.
Purpose of the Study:
- To assess the effects of various pulp treatment techniques and associated medicaments for extensive decay in primary teeth.
- To compare the clinical and radiological failure rates of different interventions.
- To evaluate secondary outcomes such as pathological root resorption and dentine bridge formation.
Main Methods:
- Systematic review and meta-analysis of randomized controlled trials.
- Searched multiple databases including Cochrane, MEDLINE, EMBASE, and Web of Science.
- Included 47 trials assessing clinical and radiological failure at 6, 12, and 24 months.
Main Results:
- Mineral trioxide aggregate (MTA) showed a trend towards reduced failures compared to formocresol (FC), but not statistically significant.
- MTA demonstrated statistically significant fewer failures than ferric sulfate (FS) at 24 months.
- Formocresol (FC) showed statistically significant advantages over calcium hydroxide (CH) and no significant difference compared to FS for certain outcomes.
Conclusions:
- No single pulp medicament or technique was clearly superior for pulpotomy in primary teeth.
- Mineral trioxide aggregate (MTA) or ferric sulfate (FS) may be preferable, with FS being a cost-effective alternative.
- Limited evidence exists for other comparisons in pulpectomy and direct pulp capping due to small study numbers.
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