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Intercellular stress reconstitution from traction force data.

Juliane Zimmermann1, Ryan L Hayes1, Markus Basan2

  • 1Center for Theoretical Biological Physics, Rice University, Houston, Texas.

Biophysical Journal
|August 8, 2014
PubMed
Summary
This summary is machine-generated.

This study validates a new method for measuring intercellular stress during collective cell migration. The findings confirm the experimental technique

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Area of Science:

  • Cellular biology
  • Biophysics
  • Mechanobiology

Background:

  • Collective cell migration is crucial for development, wound healing, and cancer metastasis.
  • A recent experimental method infers intercellular stress from substrate traction forces.
  • The validity of assuming elastic material properties for cell sheets in this method is uncertain.

Purpose of the Study:

  • To simulate collective cell migration and compute intercellular stress maps.
  • To validate the experimental method for recovering intercellular stress.
  • To assess the assumption of elastic material behavior in cell sheets.

Main Methods:

  • Simulated collective cell migration using a developed model.
  • Computed intercellular stress maps via the experimental traction force method.
  • Computed stress maps using an independent, force- and property-agnostic method.

Main Results:

  • Two independently computed intercellular stress patterns showed strong agreement.
  • The simulation results verified the validity of the experimental method.
  • The assumption of elastic material properties was supported for probed parameters.

Conclusions:

  • The experimental method for measuring intercellular stress during collective cell migration is validated.
  • The study confirms the utility of traction force microscopy in mechanobiology.
  • Accurate stress mapping aids understanding of cell-cell interactions in migration.