Related Experiment Video
Updated: Apr 26, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Using the LACE index to predict hospital readmissions in congestive heart failure patients
Hao Wang1, Richard D Robinson, Carlos Johnson
1Department of Emergency Medicine, Integrative Emergency Service, John Peter Smith Health Network, 1500 S, Main St, 76104 Fort Worth, TX, USA. hwang01@jpshealth.org.
Insights
The LACE index may not accurately predict 30-day hospital readmissions for congestive heart failure (CHF) patients. However, a high LACE score may identify patients at increased risk for emergency department revisits post-discharge.
Area of Science:
- Cardiology
- Health Services Research
- Geriatrics
Background:
- The LACE index is a tool to predict 30-day unplanned hospital readmissions.
- Its accuracy in congestive heart failure (CHF) patients requires validation.
Purpose of the Study:
- To validate the predictive accuracy of the LACE index for 30-day unplanned readmissions in CHF patients.
- To identify clinical variables associated with readmission risk in this population.
Main Methods:
- Retrospective study of 253 CHF patients.
- Calculated LACE index scores and collected clinical data.
- Used multivariate logistic regression and C-statistic to analyze readmission risk.
Main Results:
- 24.50% of patients experienced unplanned readmission within 30 days.
- LACE index scores were similar between readmitted and non-readmitted patients.
- Previous ED visits, myocardial infarction, and peripheral vascular disease history predicted readmission.
- High LACE scores (≥10) correlated with higher 30-day ED revisit rates (15.04% vs. 0%).
Conclusions:
- The LACE index demonstrated limited accuracy in predicting 30-day unplanned readmissions for CHF patients.
- The LACE index may serve as a useful screening tool for identifying patients at high risk of emergency department revisits after hospital discharge.
Background:
The LACE index has been used to predict the risk of unplanned readmission within 30 days after hospital discharge in both medical and surgical patients. The aim of this study is to validate the accuracy of using the LACE index in CHF patients.
Methods:
This was a retrospective study. The LACE index score was calculated on each patient who was admitted to hospital due to an acute CHF exacerbation. Operational and clinical variables were collected from patients including basic clinical characteristics, length of hospitalization, comorbidities, number of previous ED visits in the past 6 months before the index admission, and the number of post discharge ED revisits at 30, 60, and 90 days. All variables were analyzed by multivariate logistic regression to determine the association between clinical variables and the hospital unplanned readmissions. C-statistic was used to discriminate those patients with high risk of readmissions.
Results:
Of the 253 patients included in the study, 24.50% (62/253) experienced unplanned readmission to hospital within 30 days after discharge. The LACE index was slightly higher in patients readmitted versus patients not readmitted (12.17 ± 2.22 versus 11.80 ± 1.92, p = 0.199). Adjusted odds ratios based on logistic regression of all clinical variables showed only the number of previous ED visits (OR 1.79, 95% CI 1.30-2.47, p < 0.001), history of myocardial infarction (OR 2.51, 95% CI 1.02-6.21, p = 0.045), and history of peripheral vascular disease (OR 10.75, 95% CI 1.52-75.73, p = 0.017) increased the risk of unplanned readmission within 30 days of hospital discharge. However, patients with high LACE scores (≥10) had a significantly higher rate of ED revisits (15.04% vs 0%) within 30 days from the index discharge than those with low LACE scores (p = 0.030).
Conclusion:
The LACE index may not accurately predict unplanned readmissions within 30 days from hospital discharge in CHF patients. The LACE high risk index may have utility as a screening tool to predict high risk ED revisits after hospital discharge.
Related Concept Videos
Heart Failure VII: Nursing Interventions
Rheumatic Heart Disease IV: Nursing Management
Heart Failure IV: Classification and Diagnostic Evaluation
Heart Failure I: Introduction
Aortic Regurgitation IV: Nursing Management
Cardiomyopathy V: Interprofessional Care