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Another Shp on the horizon for bile acids

Alessia Perino1, Kristina Schoonjans1

  • 1Metabolic Signaling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

Cell Metabolism
|August 8, 2014
PubMed
Summary

Bile acid overload is toxic, so its metabolism is tightly controlled. Research identifies Shp2 as a key regulator integrating bile acid and FGF15/FGF19 signaling, adding complexity to biosynthesis control.

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