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Related Concept Videos

Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
4.3K
Sulfur Assimilation01:20

Sulfur Assimilation

549
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
549
Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

6.7K
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
6.7K
Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

6.3K
Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.
6.3K
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids01:19

Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

1.3K
Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme...
1.3K
Biosynthesis of Polysaccharides01:26

Biosynthesis of Polysaccharides

980
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
980

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Synthesis of Terpolymers at Mild Temperatures Using Dynamic Sulfur Bonds in PolyS-Divinylbenzene
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SuFEx-based synthesis of polysulfates.

Jiajia Dong1, K Barry Sharpless1, Luke Kwisnek2

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology The Scripps Research Institute La Jolla, CA 92037 (USA).

Angewandte Chemie (International Ed. in English)
|August 8, 2014
PubMed
Summary
This summary is machine-generated.

High-molecular-weight polysulfates are synthesized efficiently from aromatic bis(silyl ethers) and bis(fluorosulfates). These novel polymers offer superior chemical resistance and excellent mechanical, optical, and oxygen-barrier properties.

Keywords:
SuFEx reactionclick chemistrypolymerization

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Area of Science:

  • Polymer Chemistry
  • Materials Science

Background:

  • Aromatic bis(silyl ethers) and bis(fluorosulfates) are precursors for polymer synthesis.
  • Polysulfates are a class of polymers with potential industrial applications.

Purpose of the Study:

  • To develop a facile and efficient method for synthesizing high-molecular-weight polysulfates.
  • To evaluate the properties of the newly synthesized polysulfates.

Main Methods:

  • Polymerization of aromatic bis(silyl ethers) and bis(fluorosulfates) using a base catalyst.
  • Reaction conducted under neat conditions or in polar aprotic solvents like dimethyl formamide (DMF) or N-methylpyrrolidone (NMP).

Main Results:

  • High-molecular-weight polysulfates were formed in nearly quantitative yields.
  • The polymerization reaction was fast and efficient.
  • Synthesized polysulfates demonstrated enhanced resistance to chemical degradation compared to polycarbonates.
  • Polymers exhibited excellent mechanical, optical, and oxygen-barrier properties.

Conclusions:

  • A robust method for polysulfate synthesis has been established.
  • The resulting polysulfates possess desirable material characteristics for various applications.
  • These polysulfates represent a promising alternative to existing polymer materials.