Related Experiment Video

Updated: Apr 26, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.5K

Vitamin D, parathyroid hormone, and heart failure in a Chinese elderly population

Yi Li1, Chen Chen2, Hui Liang Liu3

  • 1Chinese PLA General Hospital at Beijing.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|August 8, 2014
PubMed

Insights

Low vitamin D and high parathyroid hormone (PTH) levels are linked to increased heart failure (HF) risk in Chinese elders. Maintaining adequate vitamin D may be crucial for cardiovascular health in this population.

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Endocrinology

Background:

  • Heart failure (HF) is a significant global health concern.
  • Low vitamin D status is increasingly recognized as a risk factor for cardiovascular disease.
  • Understanding the interplay between vitamin D, parathyroid hormone (PTH), and HF is crucial for preventative strategies.

Purpose of the Study:

  • To investigate the association between serum vitamin D and parathyroid hormone (PTH) levels and the risk of heart failure (HF).
  • To examine these associations within a population-based sample of elderly Chinese individuals.

Main Methods:

  • A cross-sectional study involving 2,047 healthy community-dwelling individuals aged 60-101 years.
  • Measurement of serum 25-hydroxyvitamin D (25[OH]D) and PTH levels using validated assays.
  • Statistical analyses included multivariate linear and logistic regression to assess associations with HF risk.

Main Results:

  • The median serum 25(OH)D level was 16.1 ng/mL and PTH was 41.5 pg/mL.
  • Both vitamin D and PTH levels showed associations with cardiac biomarkers and left ventricular ejection fraction.
  • Lower vitamin D levels (less than 10 ng/mL) were significantly associated with a higher risk of HF (HR 2.88).

Conclusions:

  • Serum 25(OH)D and PTH levels are independently associated with the risk of heart failure in the Chinese elderly.
  • These findings highlight the potential role of vitamin D and PTH in HF pathogenesis in older adults.
  • Further research may explore targeted interventions to optimize vitamin D status for cardiovascular health.
Abstract

Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.4K
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
630
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.5K
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.4K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.7K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K