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The falling incidence of hematologic cancer after heart transplantation

M G Crespo-Leiro1, J Delgado-Jiménez, L López

  • 1Hospital Universitario A Coruña, La Coruña, Spain.

Clinical Transplantation
|August 8, 2014
PubMed

Insights

Recent management changes in heart transplantation (HT) significantly lowered hematologic cancer risk. The incidence was halved in the later period, especially for long-term survivors.

Area of Science:

  • Cardiology
  • Oncology
  • Transplantation Medicine

Background:

  • Heart transplantation (HT) management has evolved, with individual changes potentially reducing post-transplant hematologic cancer risk.
  • Limited data exists on the cumulative impact of these management shifts on overall cancer incidence in HT patients.

Purpose of the Study:

  • To evaluate the overall effect of changes in heart transplantation patient management on hematologic cancer incidence.
  • To compare cancer risk between different time periods following heart transplantation.

Main Methods:

  • Utilized data from the Spanish Post-Heart-Transplantation Tumour Registry.
  • Compared incidence rates for two distinct periods: 1991-2000 and 2001-2010.

Main Results:

  • Hematologic cancer incidence was approximately 50% lower in the 2001-2010 period compared to 1991-2000.
  • The reduction in incidence was more pronounced for cases occurring more than five years post-heart transplantation.

Conclusions:

  • Combined modifications in heart transplantation patient management have successfully decreased the risk of hematologic cancer in the Spanish HT population.
  • The observed benefits on cancer risk reduction were greater for long-term outcomes (beyond five years) than for short-term outcomes.
Abstract

Keywords:
cancer incidenceheart transplantationimmunosuppressive therapylong-term complicationslymphomasmortality

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