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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Supramolecular hydrogels for long-term bioengineered stem cell therapy.

Junseok Yeom1, Su Jin Kim, Hyuntae Jung

  • 1Department of Materials Science and Engineering, 77 Cheongam-ro, Nam-gu, Pohang, 790-784, Republic of Korea.

Advanced Healthcare Materials
|August 8, 2014
PubMed
Summary

This study developed supramolecular hyaluronic acid hydrogels for long-term cell therapy. These artificial extracellular matrices successfully supported engineered mesenchymal stem cells and inhibited tumor growth in vivo.

Keywords:
host-guest interactionhyaluronic acidstem cell therapysupramolecular hydrogelstransgene expression

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Synthetic hydrogels serve as artificial extracellular matrices (ECMs) for tissue engineering.
  • Key challenges include long-term cell viability and precise spatio-temporal control of cellular cues.
  • Existing hydrogels often struggle with sustained cytocompatibility and controlled delivery.

Purpose of the Study:

  • To develop in situ supramolecularly assembled and modularly modified hydrogels for long-term engineered mesenchymal stem cell (eMSC) therapy.
  • To evaluate the cytocompatibility and therapeutic efficacy of these hydrogels in vivo.
  • To demonstrate the potential of these hydrogels as 3D artificial ECMs.

Main Methods:

  • Utilized hyaluronic acid (HA) conjugated with cucurbit[6]uril (CB[6]-HA) and diaminohexane (DAH-HA) for supramolecular assembly.
  • Incorporated drug-conjugated CB[6] (drug-CB[6]) for controlled release.
  • Encapsulated eMSCs expressing enhanced green fluorescence protein (EGFP) within the hydrogels for in vivo tracking.
  • Administered eMSCs expressing mutant interleukin-12 (IL-12M) within the hydrogels to assess tumor inhibition.

Main Results:

  • Engineered mesenchymal stem cells (eMSCs) encapsulated within CB[6]/DAH-HA hydrogels remained viable and fluorescent in mice for over 60 days.
  • Long-term expression of IL-12M by eMSCs within the hydrogels effectively inhibited tumor growth.
  • A significantly enhanced survival rate was observed in the tumor-bearing mice treated with the hydrogel system.

Conclusions:

  • Supramolecular HA hydrogels provide a viable 3D artificial ECM for long-term cell encapsulation and therapy.
  • This platform enables sustained release of therapeutic cells and molecules for enhanced treatment outcomes.
  • The findings support the application of these hydrogels in cell therapies and broader tissue engineering applications.