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Updated: Apr 26, 2026
Optimization of a Quantitative Micro-neutralization Assay
Published on: December 14, 2016
Serum neutralization assay can efficiently replace plaque reduction neutralization test for detection and
Annapia Di Gennaro1, Alessio Lorusso2, Claudia Casaccia1
1OIE Reference Laboratory for West Nile Disease, Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise, G. Caporale, Teramo, Italy.
Abstract:
A serum neutralization assay (SN) was compared with the official plaque reduction neutralization test for the quantitation of West Nile virus antibodies. A total of 1,348 samples from equid sera and 38 from human sera were tested by these two methods. Statistically significant differences were not observed, thus supporting the use of SN for routine purposes.
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