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Ultrastructural localization of thyrotropin-releasing hormone immunoreactivity in the dorsal vagal complex in rat
L Rinaman1, R R Miselis, M S Kreider
1Institute of Neurological Sciences, University of Pennsylvania, Philadelphia 19104.
Neuroscience Letters
|September 25, 1989
Abstract:
Thyrotropin-releasing hormone-like immunoreactivity (TRH-LI) was localized at the ultrastructural level in the dorsal vagal complex (DVC: dorsal motor nucleus of the vagus (DMV) and the nucleus of the solitary tract (NST] in rat. TRH-LI was concentrated in large granular vesicles in axons, presynaptic terminals, and non-synaptic axon varicosities. TRH-LI presynaptic terminals established both asymmetric and symmetric synaptic contacts with dendrites. These observations are consistent with recently described direct inhibitory and facilitatory effects of TRH on the electrical activity of neurons in the DVC.