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Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency
Svetlana Avvakumova1, Paola Fezzardi, Laura Pandolfi
1NanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Piazza della Scienza, 2, Milano, 20126, Italy. davide.prosperi@unimib.it.
Chemical Communications (Cambridge, England)
|August 8, 2014
Abstract:
A novel approach for multivalent targeting by using gold nanoparticles noncovalently decorated by tight functionalization with a cone-glycocalixarene bearing four mannose units is reported. The targeting efficiency of these multivalent nanoparticles is shown to be remarkably improved compared to that of nanoparticles bearing a monovalent mannosylated derivative.
