Transcranial direct current stimulation over left and right DLPFC: Lateralized effects on planning performance and
Katharina Heinze1, Nina Ruh2, Kai Nitschke3
1Department of Neurology, University Medical Center Freiburg, Germany; Freiburg Brain Imaging Center, University of Freiburg, Germany; Biological and Personality Psychology, Department of Psychology, University of Freiburg, Germany; Cochlear Implant Center Erlangen, ENT Department, University Hospital Erlangen, Germany.
Abstract:
Left and right dorsolateral prefrontal cortex (dlPFC) were recently found to be differentially affected by unilateral continuous theta-burst stimulation, reflected in an oppositional alteration of initial thinking time (ITT) in the Tower of London planning task. Here, we further explored this finding using bilateral transcranial direct current stimulation (tDCS) and simultaneous tracking of eye movements. Results revealed a decrease in ITT during concurrent cathodal tDCS of left dlPFC and anodal tDCS of right dlPFC. Eye-movement analyses showed that this facilitating tDCS effect was associated with the actual planning phase, thus reflecting a planning-specific impact of stimulation. For the reverse stimulation pattern of cathodal tDCS of right dlPFC and anodal tDCS of left dlPFC, an increase in gaze shifts was observed, without a significant impact on ITT. Taken together, these findings corroborate that enhanced planning performance can be obtained by boosting right dlPFC and dismantling the inhibitory impact of left dlPFC.
