Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gastritis III: Clinical Manifestations and Management

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Urinary Tract Calculi III: Medical Management

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

Gastritis-I: Introduction and Types

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fear Factor: Faculty Perceptions of Artificial Intelligence in Physician Associate Education.

The journal of physician assistant education : the official journal of the Physician Assistant Education Association·2025

Same author

An Update on Scholarly Productivity for Physician Assistant/Associate Faculty.

The journal of physician assistant education : the official journal of the Physician Assistant Education Association·2025

Same author

PAs' perspective on leadership in medicine.

JAAPA : official journal of the American Academy of Physician Assistants·2024

Same author

Enhancing Physician Assistant Psychiatry Interviewing Skills Using Standardized Patients.

The journal of physician assistant education : the official journal of the Physician Assistant Education Association·2023

Same author

Clinical Faculty Perceptions of Online Learning in Health Professions Education.

The journal of physician assistant education : the official journal of the Physician Assistant Education Association·2023

Same author

Wellens syndrome: An important consideration in patients with chest pain.

JAAPA : official journal of the American Academy of Physician Assistants·2023

Same journal

The evolution of the PA profession in Switzerland.

JAAPA : official journal of the American Academy of Physician Assistants·2026

Same journal

Use of dermoscopy and its association with skin lesion evaluation confidence among PAs in the United States.

JAAPA : official journal of the American Academy of Physician Assistants·2026

Same journal

Diabetic myonecrosis.

JAAPA : official journal of the American Academy of Physician Assistants·2026

Same journal

Acute coronary syndrome during active infusion of andexanet alfa.

JAAPA : official journal of the American Academy of Physician Assistants·2026

Same journal

Empowering PAs in health care: Unlocking the potential of implementation science.

JAAPA : official journal of the American Academy of Physician Assistants·2026

Same journal

The surgeon's tale.

JAAPA : official journal of the American Academy of Physician Assistants·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 26, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Gout: a comprehensive review.

Eric Rymal¹, Denise Rizzolo

¹Eric Rymal practices physical medicine in Hampton Roads, Va., managing acute and chronic musculoskeletal conditions. Denise Rizzolo is an associate professor in the PA program at Seton Hall University in South Orange, N.J., an assistant clinical professor in the PA program at Pace University in New York City, and practices urgent care in Springfield, N.J.The authors have disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants

|August 8, 2014

Summary

This summary is machine-generated.

Gout prevalence is rising, linked to genetic factors affecting uric acid. Diagnosis uses joint fluid analysis, imaging, and newer treatments are available for difficult cases.

More Related Videos

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Related Experiment Videos

Last Updated: Apr 26, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Rheumatology
Genetics
Metabolic Disorders

Background:

Increasing prevalence of gout in the United States population.
Association of genetic variants with abnormal uric acid metabolism.
Gout comorbidities include obesity and cardiovascular disease.

Purpose of the Study:

To summarize current understanding of gout diagnosis and management.
To highlight genetic predispositions to gout.
To discuss advanced therapeutic options.

Main Methods:

Review of genome-wide association studies for gout-related DNA variants.
Analysis of diagnostic methods including arthrocentesis, CT, and ultrasound.
Evaluation of immunologic agents for refractory gout.

Main Results:

Identification of multiple DNA sequence variants linked to gout.
Established role of imaging in supplementing diagnosis and monitoring.
Availability of novel immunologic therapies for treatment-resistant cases.

Conclusions:

Gout is a growing concern with a genetic component affecting uric acid levels.
Comprehensive diagnostic approaches combine fluid analysis with imaging.
Emerging immunotherapies offer new hope for refractory gout patients.