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Arthropod-borne bacterial diseases in pregnancy
Sarah K Dotters-Katz1, Jeffrey Kuller2, R Phillips Heine3
1Resident, Duke University.
Abstract:
Arthropod-borne bacterial diseases affect more than 25,000 Americans every year and thousands more around the world. These infections present a diagnostic dilemma for clinicians because they mimic many other pathologic conditions and are often low on or absent from the differential diagnosis list. Diagnosis is particularly challenging during pregnancy, as these infections may mimic common pregnancy-specific conditions, such as typical and atypical preeclampsia, or symptoms of pregnancy itself. Concerns regarding the safety in pregnancy of some indicated antibiotics add a therapeutic challenge for the prescriber, requiring knowledge of alternative therapeutic options for many arthropod-borne bacterial diseases. Physicians, especially those in endemic areas, must keep this class of infections in mind, particularly when the presentation does not appear classic for more commonly seen conditions. This article discusses presentation, diagnosis, and treatment of the most common of these arthropod-borne bacterial diseases, including Lyme disease, Rocky Mountain spotted fever, tick-borne relapsing fever, typhus, plague, cat-scratch disease, and Carrión disease.
Insights
Arthropod-borne bacterial diseases pose diagnostic and therapeutic challenges, especially during pregnancy. Early recognition and appropriate treatment are crucial for better patient outcomes.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Public Health
Background:
- Arthropod-borne bacterial diseases impact over 25,000 Americans annually, presenting diagnostic challenges due to non-specific symptoms.
- These infections can mimic common pregnancy conditions, complicating diagnosis and treatment in pregnant individuals.
- Clinicians may face therapeutic challenges due to antibiotic safety concerns during pregnancy.
Purpose of the Study:
- To highlight the diagnostic and therapeutic complexities of arthropod-borne bacterial diseases.
- To emphasize the importance of considering these infections in differential diagnoses, particularly in endemic areas.
- To review the presentation, diagnosis, and treatment of common arthropod-borne bacterial diseases.
Main Methods:
- Literature review of common arthropod-borne bacterial diseases.
- Discussion of clinical presentations and diagnostic approaches.
- Overview of treatment strategies, including alternative options for pregnant patients.
Main Results:
- Arthropod-borne bacterial diseases often present with ambiguous symptoms, mimicking other conditions.
- Pregnancy status introduces unique diagnostic and therapeutic hurdles.
- A range of bacterial pathogens transmitted by arthropods requires specific management.
Conclusions:
- Physicians must maintain a high index of suspicion for arthropod-borne bacterial diseases, especially in endemic regions and atypical presentations.
- Accurate diagnosis and timely, safe treatment are essential for managing these infections.
- Awareness of alternative antibiotic choices is critical for treating pregnant patients.
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